Journal article
Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity
Abstract
Aims/hypothesisObesity-related insulin resistance is associated with accumulation of bioactive lipids in skeletal muscle. The AMP-activated protein kinase (AMPK) regulates lipid oxidation in muscle by inhibiting acetyl-CoA carboxylase-2 (ACC2) and increasing mitochondrial biogenesis. We investigated whether reduced levels of muscle AMPK promote lipid accumulation and insulin resistance during high-fat feeding.MethodsMale C57/BL6 wild-type mice …
Authors
Beck Jørgensen S; O’Neill HM; Hewitt K; Kemp BE; Steinberg GR
Journal
Diabetologia, Vol. 52, No. 11, pp. 2395–2404
Publisher
Springer Nature
Publication Date
11 2009
DOI
10.1007/s00125-009-1483-8
ISSN
0012-186X