Journal article
Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation
Abstract
The leukaemia-specific fusion oncoprotein RUNX1/RUNX1T1 (AML1/ETO), resulting from the chromosomal translocation (8;21) in acute myeloid leukaemia (AML), imposes a striking genotype-phenotype relationship upon this distinct subtype of AML, which is mediated by multiple, co-ordinate downstream effects induced by this chimeric transcription factor. We previously identified the LAT2 gene, encoding the adaptor molecule LAT2 (NTAL, LAB), which is …
Authors
Duque‐Afonso J; Solari L; Essig A; Berg T; Pahl HL; Lübbert M
Journal
British Journal of Haematology, Vol. 153, No. 5, pp. 612–622
Publisher
Wiley
Publication Date
June 2011
DOI
10.1111/j.1365-2141.2011.08586.x
ISSN
0007-1048
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingAdultAgedAged, 80 and overCell DifferentiationCholecalciferolChromosomes, Human, Pair 21Chromosomes, Human, Pair 8Core Binding Factor Alpha 2 SubunitDown-RegulationFemaleGene Expression Regulation, NeoplasticGranulocytesHumansLeukemia, Myeloid, AcuteMacrophagesMaleMiddle AgedMonocytesNeoplasm ProteinsOncogene Proteins, FusionPhorbol EstersRUNX1 Translocation Partner 1 ProteinTranslocation, GeneticTumor Cells, CulturedUp-Regulation