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Lasting Effects of Low to Non-Lethal Radiation...
Journal article

Lasting Effects of Low to Non-Lethal Radiation Exposure during Late Gestation on Offspring’s Cardiac Metabolism and Oxidative Stress

Abstract

Ionizing radiation (IR) is known to cause fetal programming, but the physiological effects of low-dose IR are not fully understood. This study examined the effect of low (50 mGy) to non-lethal (300 and 1000 mGy) radiation exposure during late gestation on cardiac metabolism and oxidative stress in adult offspring. Pregnant C57BL/6J mice were exposed to 50, 300, or 1000 mGy of gamma radiation or Sham irradiation on gestational day 15. Sixteen …

Authors

Nemec-Bakk AS; Niccoli S; Davidson C; Roy D; Stoa L; Sreetharan S; Simard A; Boreham DR; Wilson JY; Tai TC

Journal

Antioxidants, Vol. 10, No. 5,

Publisher

MDPI

DOI

10.3390/antiox10050816

ISSN

2076-3921