Journal article
Antihypertensives and Statin Therapy for Primary Stroke Prevention: A Secondary Analysis of the HOPE-3 Trial
Abstract
Background and Purpose: The HOPE-3 trial (Heart Outcomes Prevention Evaluation–3) found that antihypertensive therapy combined with a statin reduced first stroke among people at intermediate cardiovascular risk. We report secondary analyses of stroke outcomes by stroke subtype, predictors, treatment effects in key subgroups.
Methods: Using a 2-by-2 factorial design, 12 705 participants from 21 countries with vascular risk factors but without …
Authors
Bosch J; Lonn EM; Dagenais GR; Gao P; Lopez-Jaramillo P; Zhu J; Pais P; Avezum A; Sliwa K; Chazova IE
Journal
Stroke, Vol. 52, No. 8, pp. 2494–2501
Publisher
Wolters Kluwer
Publication Date
8 2021
DOI
10.1161/strokeaha.120.030790
ISSN
0039-2499