Journal article
Increased DNA Synthesis and Repair-Enzyme Expression in Lymphocytes From Patients With Chronic Lymphocytic Leukemia Resistant to Nitrogen Mustards
Abstract
Resistance to the nitrogen mustards in patients with chronic lymphocytic leukemia (CLL) correlates with an enhanced removal of melphalan-induced DNA interstrand cross-links. This finding suggests that DNA repair enzymes may be involved in this process. The activity of 3-methyladenine-DNA glycosylase, which can release altered bases, including adducts at the N-7 position of guanine, was increased significantly in lymphocytes from patients with …
Authors
Geleziunas R; McQuillan A; Malapetsa A; Hutchinson M; Kopriva D; Wainberg MA; Hiscott J; Bramson J; Panasci L
Journal
Journal of the National Cancer Institute, Vol. 83, No. 8, pp. 557–564
Publisher
Oxford University Press (OUP)
Publication Date
April 17, 1991
DOI
10.1093/jnci/83.8.557
ISSN
0027-8874
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAged, 80 and overBiological TransportBlotting, NorthernChromatography, High Pressure LiquidDNA GlycosylasesDNA RepairDNA, NeoplasmDrug ResistanceFemaleHumansLeukemia, Lymphocytic, Chronic, B-CellLymphocytesMaleMelphalanMiddle AgedN-Glycosyl HydrolasesNitrogen Mustard CompoundsRNA, MessengerRNA, Neoplasm