Journal article
DNA repair enzyme expression in chronic lymphocytic leukemia vis-à-vis nitrogen mustard drug resistance
Abstract
Nitrogen mustard resistance in B-cell chronic lymphocytic leukemia (B-CLL) has been associated with enhanced DNA repair and increased expression of DNA repair enzymes. Lymphocytes from patients with nitrogen mustard resistant B-CLL displayed a fivefold increase in resistance to melphalan in vitro as compared to those from untreated patients concordant with our definition of clinical resistance. We have performed Northern analysis using a cohort …
Authors
Bramson J; McQuillan A; Panasci LC
Journal
Cancer Letters, Vol. 90, No. 2, pp. 139–148
Publisher
Elsevier
Publication Date
4 1995
DOI
10.1016/0304-3835(95)03696-t
ISSN
0304-3835
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAged, 80 and overDNA HelicasesDNA LigasesDNA Polymerase IDNA RepairDNA Topoisomerases, Type IDNA-Binding ProteinsDrug ResistanceEndonucleasesFemaleHumansInactivation, MetabolicLeukemia, Lymphocytic, Chronic, B-CellMaleMelphalanMiddle AgedNitrogen Mustard CompoundsProtein BiosynthesisProteinsRNA, MessengerTranscription FactorsTumor Cells, CulturedXeroderma Pigmentosum Group D Protein