Journal article
Nitrogen mustard drug resistant B-cell chronic lymphocytic leukemia as an in vivo model for crosslinking agent resistance
Abstract
Acquired resistance is a limiting factor in chemotherapy. We have employed nitrogen mustard resistant B-cell chronic lymphocytic leukemia (B-CLL) as a clinically relevant model to study this phenomenon. Resistance in B-CLL is associated with enhanced repair of nitrogen mustard crosslinks. In order to identify the repair pathway responsible for nitrogen mustard resistance, lymphocytes were screened for cross-resistance to a variety of DNA …
Authors
Bramson J; McQuillan A; Aubin R; Alaoui-Jamali M; Batist G; Christodoulopoulos G; Panasci LC
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 336, No. 3, pp. 269–278
Publisher
Elsevier
Publication Date
May 1995
DOI
10.1016/0921-8777(94)00063-c
ISSN
0027-5107