Journal article
A Randomized Controlled Trial to Assess the Effect of Lidocaine Administered via Throat Spray and Nebulization in Patients with Refractory Chronic Cough
Abstract
BACKGROUND: Refractory chronic cough (RCC) is a debilitating condition for which there are no licensed treatments. Lidocaine is a nonselective inhibitor of voltage-gated sodium channels with potential antitussive effects, but randomized placebo-controlled studies evaluating its efficacy in RCC are lacking.
OBJECTIVE: To investigate the efficacy of nebulized lidocaine and lidocaine throat spray versus matched placebos in RCC.
Authors
Abdulqawi R; Satia I; Kanemitsu Y; Khalid S; Holt K; Dockry R; Woodcock AA; Smith JA
Journal
The Journal of Allergy and Clinical Immunology In Practice, Vol. 9, No. 4, pp. 1640–1647
Publisher
Elsevier
Publication Date
April 2021
DOI
10.1016/j.jaip.2020.11.037
ISSN
2213-2198