Journal article
Activated thrombin‐activatable fibrinolysis inhibitor (TAFIa) attenuates fibrin‐dependent plasmin generation on thrombin‐activated platelets
Abstract
BACKGROUND: Thrombin-activated platelets can promote fibrinolysis by binding plasminogen in a fibrinogen-dependent manner and enhancing its activation by tissue-type plasminogen activator (t-PA). Whether t-PA also binds to activated platelets and the mechanism for regulation of platelet-dependent fibrinolysis remain unknown.
OBJECTIVES: Determine the mechanism of plasminogen and t-PA binding on thrombin-activated platelets and its regulation by …
Authors
Ni R; Neves MAD; Wu C; Cerroni SE; Flick MJ; Ni H; Weitz JI; Gross PL; Kim PY
Journal
Journal of Thrombosis and Haemostasis, Vol. 18, No. 9, pp. 2364–2376
Publisher
Elsevier
Publication Date
September 2020
DOI
10.1111/jth.14950
ISSN
1538-7933