Journal article
RELMα Is Induced in Airway Epithelial Cells by Oncostatin M without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo
Abstract
Resistin-like molecule alpha (RELMα) and YM-1 are secreted proteins implicated in murine models of alternatively activated macrophage (AA/M2) accumulation and Th2-skewed inflammation. Since the gp130 cytokine Oncostatin M (OSM) induces a Th2-like cytokine and AA/M2 skewed inflammation in mouse lung, we here investigated regulation of RELMα and YM-1. Transient pulmonary overexpression of OSM by Adenovirus vector (AdOSM) markedly induced RELMα …
Authors
Ho L; Yip A; Lao F; Botelho F; Richards CD
Journal
Cells, Vol. 9, No. 6,
Publisher
MDPI
DOI
10.3390/cells9061338
ISSN
2073-4409
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsArginaseCell CountCell ProliferationCytokinesEpithelial CellsExtracellular MatrixFemaleIntercellular Signaling Peptides and ProteinsInterleukin-6LectinsLectins, C-TypeLungMannose ReceptorMannose-Binding LectinsMice, Inbred BALB CMice, Inbred C57BLModels, BiologicalOncostatin MRNA, MessengerReceptors, Cell SurfaceSTAT6 Transcription FactorTh2 Cellsbeta-N-Acetylhexosaminidases