Co-enrollment of critically ill patients into multiple studies: patterns, predictors and consequences

IntroductionResearch on co-enrollment practices and their impact are limited in the ICU setting. The objectives of this study were: 1) to describe patterns and predictors of co-enrollment of patients in a thromboprophylaxis trial, and 2) to examine the consequences of co-enrollment on clinical and trial outcomes.MethodsIn an observational analysis of an international thromboprophylaxis trial in 67 ICUs, we examined the co-enrollment of …