Journal article
Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia
Abstract
Interleukin-10 (IL-10) is a potent anti-inflammatory/immune cytokine and has received growing attention for its therapeutic potential. To aid therapeutic studies of IL-10 in vivo, a replication-deficient adenoviral vector expressing mouse IL-10 was constructed and characterized. The transgene protein IL-10 was shown to markedly inhibit endotoxin-induced tumor necrosis factor α (TNFα) production by mouse and rat macrophages in vitro. …
Authors
Xing Z; Ohkawara Y; Jordana M; Graham F; Gauldie J
Journal
Gene Therapy, Vol. 4, No. 2, pp. 140–149
Publisher
Springer Nature
Publication Date
February 1, 1997
DOI
10.1038/sj.gt.3300371
ISSN
0969-7128