Journal article
Inhalation Tolerance Is Induced Selectively in Thoracic Lymph Nodes but Executed Pervasively at Distant Mucosal and Nonmucosal Tissues
Abstract
Under immunogenic conditions, both the site of initial Ag exposure and consequent T cell priming in specific draining lymph nodes (LNs) imprint the ensuing immune response with lasting tissue-selective tropism. With respect to immune tolerance, whether the site of tolerance induction leads to compartmentalized or, alternatively, pervasive tolerance has not been formally investigated. Using a murine model of inhalation tolerance, we investigated …
Authors
Alvarez D; Swirski FK; Yang T-C; Fattouh R; Croitoru K; Bramson JL; Stämpfli MR; Jordana M
Journal
The Journal of Immunology, Vol. 176, No. 4, pp. 2568–2580
Publisher
Oxford University Press (OUP)
Publication Date
February 15, 2006
DOI
10.4049/jimmunol.176.4.2568
ISSN
0022-1767