Journal article
Prostaglandin modulation of airway inflammation and hyperresponsiveness in mice sensitized without adjuvant
Abstract
As adjuvant during sensitization may cause unspecific immune reactions, the aim of the present study was to define the role of cyclooxygenase (COX) activity on airway inflammation and airway hyperresponsiveness (AHR) in an adjuvant-free allergic mouse model. Administration of diclofenac and indomethacin (non-selective COX inhibitors), FR122047 (COX-1 inhibitor) and lumiracoxib (selective COX-2 inhibitor) enhanced AHR. Only diclofenac and …
Authors
Swedin L; Ellis R; Neimert-Andersson T; Ryrfeldt Å; Nilsson G; Inman M; Dahlén S-E; Adner M
Journal
Prostaglandins and Other Lipid Mediators, Vol. 92, No. 1-4, pp. 44–53
Publisher
Elsevier
Publication Date
June 2010
DOI
10.1016/j.prostaglandins.2010.02.004
ISSN
1098-8823