Alternative outcomes for the multiple breath washout in children with CF

BACKGROUND: The lung clearance index (LCI) measured by multiple-breath washout (MBW) has been proposed as an outcome for clinical trials; however, MBW is time consuming and LCI can be affected by breathing pattern. We aimed to evaluate moment ratios and abbreviated LCI in school-aged children with mild-to-moderate CF lung disease. METHODS: Using existing data from three studies we assessed the sensitivity of moment ratios and abbreviated LCIs …