Journal article
The Myxoma Virus-soluble Interferon- γ Receptor Homolog, M-T7, Inhibits Interferon- γ in a Species-specific Manner (∗)
Abstract
The myxoma virus M-T7 protein contains significant sequence similarity to the ligand binding domain of the mammalian interferon-gamma receptors, and functions as a soluble homolog which can bind and inhibit the biological activities of rabbit interferon-gamma (Upton, C., Mossman, K., and McFadden, G. (1992) Science 258:1369-1372). M-T7, the most abundantly secreted protein from myxoma virus-infected cells, was shown to be expressed in …
Authors
Mossman K; Upton C; McFadden G
Journal
Journal of Biological Chemistry, Vol. 270, No. 7, pp. 3031–3038
Publisher
Elsevier
Publication Date
February 1995
DOI
10.1074/jbc.270.7.3031
ISSN
0021-9258
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAnimalsBase SequenceBinding SitesCell LineDNA PrimersGenes, ViralInterferon-gammaKineticsMammalsMolecular Sequence DataMyxoma virusRabbitsReceptors, InterferonRecombinant ProteinsSequence Homology, Amino AcidSpecies SpecificityTranscription, GeneticViral ProteinsInterferon gamma Receptor