Journal article
Cystathionine β-Lyase Is Important for Virulence of Salmonella enterica Serovar Typhimurium
Abstract
The biosynthesis of methionine in bacteria requires the mobilization of sulfur from Cys by the formation and degradation of cystathionine. Cystathionine beta-lyase, encoded by metC in bacteria and STR3 in Schizosaccharomyces pombe, catalyzes the breakdown of cystathionine to homocysteine, the penultimate step in methionine biosynthesis. This enzyme has been suggested to be the target for pyridinamine antimicrobial agents. We have demonstrated, …
Authors
Ejim LJ; D'Costa VM; Elowe NH; Loredo-Osti JC; Malo D; Wright GD
Journal
Infection and Immunity, Vol. 72, No. 6, pp. 3310–3314
Publisher
American Society for Microbiology
Publication Date
6 2004
DOI
10.1128/iai.72.6.3310-3314.2004
ISSN
0019-9567