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The Wall Teichoic Acid Polymerase TagF Efficiently...

Journal article

The Wall Teichoic Acid Polymerase TagF Efficiently Synthesizes Poly(glycerol phosphate) on the TagB Product Lipid III

Abstract

One piece at a time: Glycerol phosphate polymerization by the TagF enzyme is investigated through the use of a synthetic analogue of a teichoic acid intermediate. Analysis of polymerization products and reaction kinetics of the enzyme suggest a distributive assembly of the teichoic acid polymer on the TagB product lipid III.

Authors

Pereira MP; Schertzer JW; D'Elia MA; Koteva KP; Hughes DW; Wright GD; Brown ED

Journal

ChemBioChem, Vol. 9, No. 9, pp. 1385–1390

Publisher

Wiley

Publication Date

June 16, 2008

DOI

10.1002/cbic.200800026

ISSN

1439-4227

Associated Experts

Eric Brown

Professor, Faculty of Health Sciences

Gerard Wright

Scientific Director, Faculty of Health Sciences

Jonathan Schertzer

Professor, Faculty of Health Sciences

Labels

Fields of Research (FoR)

3101 Biochemistry and cell biology 31 Biological Sciences 3404 Medicinal and biomolecular chemistry

Medical Subject Headings (MeSH)

Cell Wall Glycerophosphates Glycosphingolipids Teichoic Acids Transferases (Other Substituted Phosphate Groups)

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