Journal article
NGF mRNA is not decreased in frontal cortex from Alzheimer's Disease patients
Abstract
Alzheimer's disease (AD) is characterized by neuronal dysfunction and degeneration in certain brain regions such as cortex, hippocampus and basal forebrain. Specific neurochemical defects such as decreases in cholinergic enzymes and in the amounts of mRNA in AD brain have also been reported. Nerve growth factor (NGF), a protein necessary for the development, regulation and survival of basal forebrain cholinergic neurons (BFCN), is synthesized …
Authors
Jetté N; Cole MS; Fahnestock M
Journal
Brain Research, Vol. 25, No. 3-4, pp. 242–250
Publisher
Elsevier
Publication Date
September 1994
DOI
10.1016/0169-328x(94)90159-7
ISSN
0006-8993