Journal article
Uncertainties in baseline risk estimates and confidence in treatment effects
Abstract
The GRADE system provides a framework for evaluating how risk of bias, publication bias, imprecision, inconsistency, and indirectness may reduce confidence in estimates of relative effects of interventions on outcomes. However, GRADE and all other systems for rating confidence in effect estimates do not fully address uncertainty in baseline risk and its impact on confidence in absolute estimates of treatment effect. In this article the authors …
Authors
Spencer FA; Iorio A; You J; Murad MH; Schünemann HJ; Vandvik PO; Crowther MA; Pottie K; Lang ES; Meerpohl JJ
Journal
The BMJ, Vol. 345, No. nov14 1,
Publisher
BMJ
Publication Date
November 14, 2012
DOI
10.1136/bmj.e7401
ISSN
0959-8138