Journal article
Type and intensity of FVIII exposure on inhibitor development in PUPs with haemophilia A
Abstract
The impact of treatment-related factors on inhibitor development in previously untreated patients (PUPs) with haemophilia A is still debated. We present the results of a collaborative, individual patient data meta-analytic project. Eligible data sources were published cohorts of PUPs for which patient-level data were available. The exposures of interest were factor (F)VIII type (recombinant [rFVIII] vs plasma-derived [pdFVIII]) and treatment …
Authors
Marcucci M; Mancuso ME; Santagostino E; Kenet G; Elalfy M; Holzhauer S; Bidlingmaier C; Escuriola Ettingshausen C; Iorio A; Nowak-Göttl U
Journal
Thrombosis and Haemostasis, Vol. 113, No. 05, pp. 958–967
Publisher
Thieme
Publication Date
September 2015
DOI
10.1160/th14-07-0621
ISSN
0340-6245