Journal article
A role for the TGFβ-Par6 polarity pathway in breast cancer progression
Abstract
The role of polarity signaling in cancer metastasis is ill defined. Using two three-dimensional culture models of mammary epithelial cells and an orthotopic mouse model of breast cancer, we reveal that Par6 signaling, which is regulated directly by TGFbeta, plays a role in breast cancer metastasis. Interference with Par6 signaling blocked TGFbeta-dependent loss of polarity in acini-like structures formed by non-transformed mammary cells grown …
Authors
Viloria-Petit AM; David L; Jia JY; Erdemir T; Bane AL; Pinnaduwage D; Roncari L; Narimatsu M; Bose R; Moffat J
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 33, pp. 14028–14033
Publisher
Proceedings of the National Academy of Sciences
Publication Date
August 18, 2009
DOI
10.1073/pnas.0906796106
ISSN
0027-8424