Selection bias in occupational case‐control studies that use death registries to select subjects: A discussion and demonstration

Some epidemiologic studies have selected subjects from death registries. This method is, however, subject to substantial systematic bias that arises from the fact that different segments of society have different risks of death in any year. Different occupational groups will thus have unequal probabilities of entering the pool of potential controls, and biased estimates of the odds ratios that relate occupation to disease will result. Failure …