Impact of ACE2 gene polymorphism on antihypertensive efficacy of ACE inhibitors

Angiotensin-converting enzyme 2 (ACE2), a newly discovered member of renin–angiotensin–aldosterone system, counterbalances the actions of angiotensin-converting enzyme. The objective of our study was to assess the association between rs2106809 polymorphism in ACE2 gene and the blood pressure response to ACE inhibitors in untreated hypertensive patients. After a 2-week, double-blind placebo run-in period, either benazepril or imidapril was …