Journal article
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Abstract
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood …
Authors
Evangelou E; Warren HR; Mosen-Ansorena D; Mifsud B; Pazoki R; Gao H; Ntritsos G; Dimou N; Cabrera CP; Karaman I
Journal
Nature Genetics, Vol. 50, No. 10, pp. 1412–1425
Publisher
Springer Nature
Publication Date
10 2018
DOI
10.1038/s41588-018-0205-x
ISSN
1061-4036
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AdultAgedAged, 80 and overBlood PressureCardiovascular DiseasesCells, CulturedFemaleGenetic LociGenetic Predisposition to DiseaseGenetic TestingGenetics, PopulationGenome-Wide Association StudyHuman Umbilical Vein Endothelial CellsHumansHypertensionLife StyleMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociRisk Factors