Journal article
An Ep-ICD Based Index Is a Marker of Aggressiveness and Poor Prognosis in Thyroid Carcinoma
Abstract
BACKGROUND: Nuclear accumulation of the intracellular domain of epithelial cell adhesion molecule (Ep-ICD) in tumor cells was demonstrated to predict poor prognosis in thyroid carcinoma patients in our earlier study. Here, we investigated the clinical significance of Ep-ICD subcellular localization index (ESLI) in distinguishing aggressive papillary thyroid carcinoma (PTC) from non-aggressive cases.
METHODS: Using domain specific antibodies …
Authors
He HC-H; Kashat L; Kak I; Kunavisarut T; Gundelach R; Kim D; So AK-C; MacMillan C; Freeman JL; Ralhan R
Journal
PLOS ONE, Vol. 7, No. 9,
Publisher
Public Library of Science (PLoS)
Publication Date
2012
DOI
10.1371/journal.pone.0042893
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAgedAged, 80 and overAntigens, NeoplasmArea Under CurveBiomarkers, TumorCarcinomaCarcinoma, PapillaryCell Adhesion MoleculesDisease-Free SurvivalEpithelial Cell Adhesion MoleculeFemaleGene ExpressionHumansMaleMiddle AgedNeoplasm GradingNeoplasm InvasivenessPrognosisProtein Structure, TertiaryROC CurveResearch DesignThyroid Cancer, PapillaryThyroid GlandThyroid Neoplasms