Journal article
N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation
Abstract
The huntingtin N17 domain is a modulator of mutant huntingtin toxicity and is hypophosphorylated in Huntington's disease (HD). We conducted high-content analysis to find compounds that could restore N17 phosphorylation. One lead compound from this screen was N6-furfuryladenine (N6FFA). N6FFA was protective in HD model neurons, and N6FFA treatment of an HD mouse model corrects HD phenotypes and eliminates cortical mutant huntingtin inclusions. …
Authors
Bowie LE; Maiuri T; Alpaugh M; Gabriel M; Arbez N; Galleguillos D; Hung CLK; Patel S; Xia J; Hertz NT
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 30, pp. e7081–e7090
Publisher
Proceedings of the National Academy of Sciences
Publication Date
July 24, 2018
DOI
10.1073/pnas.1801772115
ISSN
0027-8424