Journal article
Effects of ticagrelor versus clopidogrel on platelet function in fibrinolytic-treated STEMI patients undergoing early PCI
Abstract
OBJECTIVES: Patients undergoing PCI early after fibrinolytic therapy are at high risk for both thrombotic and bleeding complications. We sought to assess the pharmacodynamic effects of ticagrelor versus clopidogrel in the fibrinolytic-treated STEMI patients undergoing early PCI.
METHODS AND RESULTS: Patients undergoing PCI within 24 hours of tenecteplase (TNK), aspirin, and clopidogrel for STEMI were randomized to receive additional clopidogrel …
Authors
Dehghani P; Lavoie A; Lavi S; Crawford JJ; Harenberg S; Zimmermann RH; Booker J; Kelly S; Cantor WJ; Mehta SR
Journal
American Heart Journal, Vol. 192, , pp. 105–112
Publisher
Elsevier
Publication Date
October 2017
DOI
10.1016/j.ahj.2017.07.013
ISSN
0002-8703
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenosineBlood PlateletsClopidogrelDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansMaleMiddle AgedPercutaneous Coronary InterventionPlatelet ActivationPlatelet Aggregation InhibitorsPreoperative CarePrognosisProspective StudiesPurinergic P2Y Receptor AntagonistsST Elevation Myocardial InfarctionThrombolytic TherapyTicagrelorTiclopidineTime Factors