Journal article
PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice
Abstract
BACKGROUND AND AIMS: PDZK1 (Post-synaptic density protein/Drosophila disc-large protein/Zonula occludens protein containing 1) stabilizes the HDL receptor protein, SR-B1, in the liver, and mediates SR-B1 signaling outside of the liver. Complete knockout of pdzk1 increases atherosclerosis in apoE-deficient mice, but the effect of PDZK1 in leukocytes is not known. In this study, we tested the role of leukocyte PDZK1 in atherosclerosis development …
Authors
Yu P; Qian AS; Chathely KM; Trigatti BL
Journal
Atherosclerosis, Vol. 276, , pp. 171–181
Publisher
Elsevier
Publication Date
9 2018
DOI
10.1016/j.atherosclerosis.2018.05.009
ISSN
0021-9150
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisAtherosclerosisBone Marrow TransplantationDiet, High-FatDisease Models, AnimalGenetic Predisposition to DiseaseHumansIntracellular Signaling Peptides and ProteinsJurkat CellsLeukocytesLipoproteins, HDLMacrophages, PeritonealMaleMembrane ProteinsMice, Inbred C57BLMice, KnockoutNecrosisPhenotypePlaque, AtheroscleroticProto-Oncogene Proteins c-aktReceptors, LDLSignal Transduction