Journal article
Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation
Abstract
RATIONALE: Restoration of coronary artery blood flow is the most effective means of ameliorating myocardial damage triggered by ischemic heart disease. However, coronary reperfusion elicits an increment of additional injury to the myocardium. Accumulating evidence indicates that the unfolded protein response (UPR) in cardiomyocytes is activated by ischemia/reperfusion (I/R) injury. Xbp1s (spliced X-box binding protein 1), the most highly …
Authors
Bi X; Zhang G; Wang X; Nguyen C; May HI; Li X; Al-Hashimi AA; Austin RC; Gillette TG; Fu G
Journal
Circulation Research, Vol. 122, No. 11, pp. 1545–1554
Publisher
Wolters Kluwer
Publication Date
May 25, 2018
DOI
10.1161/circresaha.117.312641
ISSN
0009-7330
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisCells, CulturedEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsMiceMice, Inbred C57BLMice, TransgenicMyocardial IschemiaMyocardial Reperfusion InjuryMyocytes, CardiacOxidative StressPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsReactive Oxygen SpeciesUnfolded Protein ResponseUp-Regulation