Journal article
Dimensions of the ion channel in neuronal nicotinic acetylcholine receptor as estimated from analysis of conformation-activity relationships of open-channel blocking drugs
Abstract
Relationship between the size of the molecule in the series of organic ions Et3N−(CH2)5−N+R1R2R3 (Ri-alkyl or cycloalkyl substituents) and their abilities to block nicotinic acetylcholine receptors (AChRs) due to their open-channel blockade in the neurons of autonomic ganglia and in frog end-plate was analyzed.All low-energy equilibrium conformations of the drugs were calculated by the molecular mechanics method. A unique rectangular channel …
Authors
Zhorov BS; Brovtsyna NB; Gmiro VE; Lukomskaya NY; Serdyuk SE; Potapyeva NN; Magazanik LG; Kurenniy DE; Skok VI
Journal
The Journal of Membrane Biology, Vol. 121, No. 2, pp. 119–132
Publisher
Springer Nature
Publication Date
4 1991
DOI
10.1007/bf01870527
ISSN
0022-2631