Journal article
Effects of the Once-Weekly Glucagon-Like Peptide-1 Receptor Agonist Dulaglutide on Ambulatory Blood Pressure and Heart Rate in Patients With Type 2 Diabetes Mellitus
Abstract
Glucagon-like peptide-1 receptor agonists, used to treat type 2 diabetes mellitus, are associated with small reductions in systolic blood pressure (SBP) and increases in heart rate. However, findings based on clinic measurements do not adequately assess a drug's 24-hour pharmacodynamic profile. The effects of dulaglutide, a once-weekly glucagon-like peptide-1 receptor agonist, on BP and heart rate were investigated using ambulatory BP …
Authors
Ferdinand KC; White WB; Calhoun DA; Lonn EM; Sager PT; Brunelle R; Jiang HH; Threlkeld RJ; Robertson KE; Geiger MJ
Journal
Hypertension, Vol. 64, No. 4, pp. 731–737
Publisher
Wolters Kluwer
Publication Date
10 2014
DOI
10.1161/hypertensionaha.114.03062
ISSN
0194-911X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedBlood PressureBlood Pressure Monitoring, AmbulatoryDiabetes Mellitus, Type 2DiarrheaDouble-Blind MethodDrug Administration ScheduleFemaleGlucagon-Like Peptide-1 ReceptorGlucagon-Like PeptidesGlycated HemoglobinHeart RateHumansHypoglycemic AgentsImmunoglobulin Fc FragmentsInjections, SubcutaneousMaleMiddle AgedNauseaReceptors, GlucagonRecombinant Fusion ProteinsTreatment OutcomeVomiting