The Perception of Breathlessness in Asthma1–3

We studied the perception of breathlessness as a function of air flow obstruction in 45 asthmatic subjects using a category scaling technique. Air flow obstruction and breathlessness were induced by inhalations of histamine acid phosphate in twofold-increasing concentrations from 0.03 to 16 mg/ml. The FEV1 was measured after each inhalation of histamine, and the subject was asked to rate his symptoms of breathlessness. The results showed that …