Journal article
Argatroban Anticoagulation in Patients With Heparin-Induced Thrombocytopenia
Abstract
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is an intensely prothrombotic syndrome managed by discontinuation of heparin therapy and substitution of an alternative inhibitor of thrombin. We describe our experience with argatroban, a direct thrombin inhibitor, in patients with HIT or HIT with thrombosis (HITTS).
METHODS: In this multicenter, nonrandomized prospective study, 418 patients with HIT were administered intravenous argatroban, 2 …
Authors
Lewis BE; Wallis DE; Leya F; Hursting MJ; Kelton JG
Journal
JAMA Internal Medicine, Vol. 163, No. 15, pp. 1849–1856
Publisher
American Medical Association (AMA)
Publication Date
August 11, 2003
DOI
10.1001/archinte.163.15.1849
ISSN
2168-6106