Journal article
Reduction of thrombus size in murine models of thrombosis following administration of recombinant α1-proteinase inhibitor mutant proteins
Abstract
The variant serpin α1-PI M358R inhibits thrombin and other proteases such as activated protein C (APC) and factor XIa. We previously described recombinant proteins HAPI M358R (α1-PI M358R containing an N-terminal extension corresponding to residues 1-75 of heparin cofactor II) and HAPI RCL5 (HAPI M358R with F352-I356 and I360 substituted for the corresponding residues of antithrombin), with enhanced selectivity for thrombin over APC inhibition. …
Authors
Sheffield WP; Eltringham-Smith LJ; Bhakta V; Gataiance S
Journal
Thrombosis and Haemostasis, Vol. 107, No. 05, pp. 972–984
Publisher
Thieme
Publication Date
2012
DOI
10.1160/th11-09-0604
ISSN
0340-6245
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntithrombinsCarotid Artery InjuriesChloridesDisease Models, AnimalDose-Response Relationship, DrugEndotoxemiaEndotoxinsFactor XIIaFactor XIaFactor XaFactor Xa InhibitorsFerric CompoundsFibrinogenFibrinolytic AgentsHemorrhageInjections, IntravenousKineticsLeukocyte ElastaseMiceMutationNG-Nitroarginine Methyl EsterRecombinant Fusion ProteinsThrombinThrombosisalpha 1-Antitrypsin