Angiotensin II mobilizes intracellular calcium and activates pannexin‐1 channels in rat carotid body type II cells via AT1 receptors

Key points A locally generating, angiotensin II (ANG II) system is present in the rat carotid body (CB) and up‐regulation of this system occurs in certain pathophysiological situations, enhancing sympathetic activity. Here, we show that, similar to chemoreceptor type I cells, glial‐like type II cells also express functional AT 1 Rs, stimulation of which causes release of Ca 2+ from intracellular stores. ANG II–AT 1 R signalling in …