Journal article
Neuroimmunologic and Neurotrophic Interactions in Autism Spectrum Disorders: Relationship to Neuroinflammation
Abstract
Autism spectrum disorders (ASD) are the most prevalent set of pediatric neurobiological disorders. The etiology of ASD has both genetic and environmental components including possible dysfunction of the immune system. The relationship of the immune system to aberrant neural circuitry output in the form of altered behaviors and communication characterized by ASD is unknown. Dysregulation of neurotrophins such as BDNF and their signaling pathways …
Authors
Ohja K; Gozal E; Fahnestock M; Cai L; Cai J; Freedman JH; Switala A; El-Baz A; Barnes GN
Journal
NeuroMolecular Medicine, Vol. 20, No. 2, pp. 161–173
Publisher
Springer Nature
Publication Date
6 2018
DOI
10.1007/s12017-018-8488-8
ISSN
1535-1084
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Autism Spectrum DisorderBrain-Derived Neurotrophic FactorChildGene-Environment InteractionHumansImmunizationInfectionsIntercellular Signaling Peptides and ProteinsMicrogliaModels, ImmunologicalNerve Growth FactorsNeuroimmunomodulationReceptor Protein-Tyrosine KinasesSignal TransductionT-Lymphocyte SubsetsTransforming Growth Factor betaWnt Signaling Pathway