Journal article
Effect of L-prolyl-L-leucyl-glycinamide (PLG) on neuroleptic-induced catalepsy and dopamine/neuroleptic receptor bindings
Abstract
The mechanism of action subserving the potential anti-Parkinsonian properties of L-prolyl-L-leucyl-glycinamide (PLG) was investigated in behavioural and neurochemical models of dopaminergic function in the rat. Acute administration of PLG (20 and 40 mg kg-1 SC) failed to alter appreciably the intensity of the cataleptic response elicited by haloperidol (3 mg kg-1 IP). By contrast, chronic PLG treatment (20, 40 and 80 mg kg-1 SC twice daily for …
Authors
Chiu S; Paulose CS; Mishra RK
Journal
Peptides, Vol. 2, No. 1, pp. 105–111
Publisher
Elsevier
Publication Date
3 1981
DOI
10.1016/s0196-9781(81)80019-8
ISSN
0196-9781