Conference
Cyclooxygenase isoenzymes and patency of ductus arteriosus
Abstract
Prenatal patency of the ductus arteriosus is maintained mainly by prostaglandin (PG) E(2). Accordingly, the vessel is endowed in its muscular component with a complete, cyclooxygenase (COX) and PGE synthase (PGES), system for the synthesis of the compound. COX1 is better expressed than COX2, particularly in the premature, but COX2 is more extensively coupled with microsomal PGES (mPGES). No evidence was obtained of either COX being coupled with …
Authors
Coceani F; Barogi S; Brizzi F; Ackerley C; Seidlitz E; Kelsey L; Ballou LR; Baragatti B
Volume
72
Pagination
pp. 71-77
Publisher
Elsevier
Publication Date
February 2005
DOI
10.1016/j.plefa.2004.10.004
Conference proceedings
Prostaglandins Leukotrienes and Essential Fatty Acids
Issue
2
ISSN
0952-3278