UNC-129 regulates the balance between UNC-40...

Abstract

In the worm, netrin and the TGFβ-related molecule UNC-129 form opposing dorsoventral gradients. Motor axons are repelled by netrin and attracted to UNC-129, but no TGFβ receptors appear to be involved in the attraction. This study shows that UNC-129 enhances repulsive signaling from the netrin receptor complex UNC-5/UNC-40, via a direct interaction with UNC-5.

Authors

MacNeil LT; Hardy WR; Pawson T; Wrana JL; Culotti JG

Journal

Nature Neuroscience, Vol. 12, No. 2, pp. 150–155

Publisher

Springer Nature

Publication Date

February 1, 2009

DOI

10.1038/nn.2256

ISSN

1097-6256

Associated Experts

Lesley MacNeil

Associate Professor, Faculty of Health Sciences

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Labels

Fields of Research (FoR)

32 Biomedical and Clinical Sciences 3209 Neurosciences 5202 Biological psychology

Medical Subject Headings (MeSH)

Animals Axons COS Cells Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Adhesion Molecules Cell Movement Chlorocebus aethiops Gene Expression Regulation, Developmental Growth Cones Mutagenesis Nervous System Neurons Receptors, Cell Surface Signal Transduction Transforming Growth Factor beta

UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways