Journal article
Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13
Abstract
Leukemic transformation of human cells is a complex process. Here we show that forced expression of MN1 in primitive human cord blood cells maintained on stromal cells in vitro induces a transient, but not serially transplantable, myeloproliferation in engrafted mice. However, cotransduction of an activated HOX gene (NUP98HOXD13) with MN1 induces a serially transplantable acute myeloid leukemia (AML). Further characterization of the leukemic …
Authors
Imren S; Heuser M; Gasparetto M; Beer PA; Norddahl GL; Xiang P; Chen L; Berg T; Rhyasen GW; Rosten P
Journal
Blood, Vol. 124, No. 24, pp. 3608–3612
Publisher
American Society of Hematology
Publication Date
December 4, 2014
DOI
10.1182/blood-2014-04-564666
ISSN
0006-4971