Journal article
AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5
Abstract
OBJECTIVE: Insulin resistance associated with obesity and diabetes is ameliorated by specific overexpression of GLUT4 in skeletal muscle. The molecular mechanisms regulating skeletal muscle GLUT4 expression remain to be elucidated. The purpose of this study was to examine these mechanisms.
RESEARCH DESIGN AND METHODS AND RESULTS: Here, we report that AMP-activated protein kinase (AMPK) regulates GLUT4 transcription through the histone …
Authors
McGee SL; van Denderen BJW; Howlett KF; Mollica J; Schertzer JD; Kemp BE; Hargreaves M
Journal
Diabetes, Vol. 57, No. 4, pp. 860–867
Publisher
American Diabetes Association
Publication Date
April 1, 2008
DOI
10.2337/db07-0843
ISSN
0012-1797