Oral rabeprazole vs. intravenous pantoprazole: a comparison of the effect on intragastric pH in healthy subjects Journal Articles uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • SummaryBackgroundIntravenous pantoprazole is often administered inappropriately to hospitalized patients who can take oral medications.AimTo compare the antisecretory effects of oral rabeprazole and intravenous pantoprazole in healthy subjects.MethodsIn a double‐blind, double‐dummy, two‐way crossover study, 38 Helicobacter pylori‐negative volunteers were randomized to oral rabeprazole 20 mg or intravenous pantoprazole 40 mg daily for 3 days followed, after a 14‐day washout period by the comparator treatment. Intragastric pH was recorded continuously for 24 h at baseline and on days 1 and 3 of each treatment period.ResultsThe mean (95% CI) percentage of the 24‐h recording with gastric pH >4 was higher with rabeprazole than with pantoprazole on day 1: 37.7% (30.6–44.8%) vs. 23.9% (20.0–27.8). The mean percentage times with pH >3 and >4 for all intervals assessed were greater and the median 24‐h intragastric pH values were higher with rabeprazole than with pantoprazole on days 1 and 3. The mean acidity index was lower with rabeprazole on days 1 and 3.ConclusionsOral rabeprazole 20 mg produced greater acid suppression than intravenous pantoprazole 40 mg. Therefore, it may be an appropriate and effective alternative in patients who can take oral medication.


  • Armstrong, David
  • JAMES, C
  • CHEN, Y

publication date

  • January 2007