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Acetylcholine and caffeine activate Cl- and...

Journal article

Acetylcholine and caffeine activate Cl- and suppress K+ conductances in human bronchial smooth muscle

Abstract

The conductance changes underlying agonist-evoked depolarization in human airway smooth muscle (ASM) were examined using single ASM cells liberated enzymatically from noncarcinomatous bronchi and studied using patch-clamp techniques. Step commands to potentials at or more positive than the resting membrane potential evoked outward current, which was predominantly delayed rectifier K+ current with some Ca(2+)-dependent K+ current Caffeine (5 …

Authors

Janssen LJ

Journal

American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 270, No. 5, pp. L772–L781

Publisher

American Physiological Society

Publication Date

May 1, 1996

DOI

10.1152/ajplung.1996.270.5.l772

ISSN

1040-0605

Associated Experts

Luke Jeffrey Janssen

Professor Emeritus, Faculty of Health Sciences

Labels

Medical Subject Headings (MeSH)

Acetylcholine Bronchi Caffeine Calcium Chlorides Electric Conductivity Humans Muscle, Smooth Potassium Reaction Time

Fields of Research (FoR)

3201 Cardiovascular medicine and haematology 3208 Medical physiology

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