Journal article
Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke
Abstract
BACKGROUND: Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel.
METHODS: In this double-blind, 2-by-2 factorial trial, we randomly assigned patients to receive 25 mg of aspirin plus 200 mg of extended-release dipyridamole twice daily or to receive 75 mg of clopidogrel daily. The …
Authors
Sacco RL; Diener H-C; Yusuf S; Cotton D; Ounpuu S; Lawton WA; Palesch Y; Martin RH; Albers GW; Bath P
Journal
New England Journal of Medicine, Vol. 359, No. 12, pp. 1238–1251
Publisher
Massachusetts Medical Society
Publication Date
September 18, 2008
DOI
10.1056/nejmoa0805002
ISSN
0028-4793
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAngiotensin-Converting Enzyme InhibitorsAspirinBenzimidazolesBenzoatesBrain IschemiaClopidogrelDelayed-Action PreparationsDipyridamoleDouble-Blind MethodDrug Therapy, CombinationFactor Analysis, StatisticalFemaleHemorrhageHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsProportional Hazards ModelsRiskSecondary PreventionStrokeTelmisartanTiclopidineVascular Diseases