Journal article
Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study
Abstract
BACKGROUND: The treatment of ischaemic stroke with neuroprotective drugs has been unsuccessful, and whether these compounds can be used to reduce disability after recurrent stroke is unknown. The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial.
METHODS: Patients who had had an …
Authors
Diener H-C; Sacco RL; Yusuf S; Cotton D; Ôunpuu S; Lawton WA; Palesch Y; Martin RH; Albers GW; Bath P
Journal
The Lancet Neurology, Vol. 7, No. 10, pp. 875–884
Publisher
Elsevier
Publication Date
10 2008
DOI
10.1016/s1474-4422(08)70198-4
ISSN
1474-4422
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAngiotensin II Type 1 Receptor BlockersAspirinBenzimidazolesBenzoatesClopidogrelCognitionDipyridamoleDisability EvaluationDouble-Blind MethodDrug Administration ScheduleDrug Delivery SystemsDrug Therapy, CombinationFemaleFollow-Up StudiesHumansInternational CooperationMaleMental Status ScheduleMiddle AgedPlatelet Aggregation InhibitorsRetrospective StudiesSecondary PreventionSeverity of Illness IndexStrokeTelmisartanTiclopidine