Identification of Mutations in Proviral Long Terminal Repeats of HIV Type 1-Infected Subjects Naive to Drug Therapy Journal Articles uri icon

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  • Human immunodeficiency virus type 1 (HIV-1) proviral DNA sequences in the 5' long terminal repeat (LTR) were examined among 28 drug-naive individuals. Twenty-four subjects had highly conserved LTR sequences, however, more significant changes were observed in the remaining four LTR sequences. These included a 9-bp deletion preceding the NF kappa B elements and a duplication of the RBF-2 motif. A higher overall frequency of mutations within the LTR occurred within NFAT-1 and Sp-1 sequences. Importantly, a novel 16-bp deletion was found in the distal NFAT-1 site.


  • Copeland, Karen FT
  • Chen, Zhaoxia
  • Fiebig, Marnie
  • Ni, Lisa
  • Savoy, Sherie
  • Smaill, Fiona
  • Rosenthal, Kenneth L
  • Kim, John E

publication date

  • September 2004