Journal article
Combined intensive blood pressure and glycemic control does not produce an additive benefit on microvascular outcomes in type 2 diabetic patients
Abstract
A reduction of either blood pressure or glycemia decreases some microvascular complications of type 2 diabetes, and we studied here their combined effects. In total, 4733 older adults with established type 2 diabetes and hypertension were randomly assigned to intensive (systolic blood pressure less than 120 mm Hg) or standard (systolic blood pressure less than 140 mm Hg) blood pressure control, and separately to intensive (HbA1c less than …
Authors
Ismail-Beigi F; Craven TE; O'Connor PJ; Karl D; Calles-Escandon J; Hramiak I; Genuth S; Cushman WC; Gerstein HC; Probstfield JL
Journal
Kidney International, Vol. 81, No. 6, pp. 586–594
Publisher
Elsevier
Publication Date
March 2012
DOI
10.1038/ki.2011.415
ISSN
0085-2538
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAlbuminuriaAntihypertensive AgentsBiomarkersBlood GlucoseBlood PressureCreatinineDiabetes Mellitus, Type 2Diabetic RetinopathyDouble-Blind MethodFemaleGlycated HemoglobinHumansHypertensionHypoglycemic AgentsMaleMicrocirculationMiddle AgedProportional Hazards ModelsRenal InsufficiencyRisk AssessmentRisk FactorsTime FactorsTreatment Outcome