Journal article
Probing modifications of the neuronal cytoskeleton
Abstract
The prominent death of central neurons in Alzheimer's and Parkinson's is reflected by changes in cell shape and by the formation of characteristic cytoskeletal inclusions (neurofibrillary tangles, Lewy bodies). This review focuses on the biology of neurofilaments and microtubule-associated proteins and identifies changes that can occur to these elements from basic and clinical research perspectives. Attention is directed at certain advances in …
Authors
Doering LC
Journal
Molecular Neurobiology, Vol. 7, No. 3-4, pp. 265–291
Publisher
Springer Nature
Publication Date
9 1993
DOI
10.1007/bf02769179
ISSN
0893-7648
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AluminumAlzheimer DiseaseAmyloid beta-PeptidesAnimalsAnimals, Genetically ModifiedAxonsBrain Tissue TransplantationCytoskeletal ProteinsCytoskeletonMammalsMiceNerve DegenerationNerve Tissue ProteinsNeuronsNeurotoxinsPC12 CellsParkinson DiseasePhosphorylationProtein Processing, Post-TranslationalRats