Journal article
The WAGxDA rat: An animal model of cholinergic supersensitivity
Abstract
A heightened response to the muscarinic effects of acetylcholine appears to be involved in many of the symptoms associated with affective disorders. We have developed an animal model for cholinergic supersensitivity to study this involvement in more detail. Our findings on cholinergic supersensitivity and on behavioral despair in this model, the WAGxDA F1 hybrid, are reported here. Female WAGxDA rats show a heightened response to muscarinic …
Authors
Orpen G; Steiner M
Journal
Biological Psychiatry, Vol. 37, No. 12, pp. 874–883
Publisher
Elsevier
Publication Date
6 1995
DOI
10.1016/0006-3223(94)00250-7
ISSN
0006-3223
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAutonomic Nervous System DiseasesBehavior, AnimalBody TemperatureBrain ChemistryDisease Models, AnimalFemaleKineticsMaleMuscarinic AgonistsN-MethylscopolamineOxotremorineParasympathetic Nervous SystemParasympatholyticsRatsRats, Inbred StrainsReceptors, MuscarinicScopolamine DerivativesStress, Psychological